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Related Concept Videos

The Mammary Glands01:12

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The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
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Updated: May 9, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Columnar cell-like changes in the male breast.

Yun-Bi Ni1, Shafaq Mujtaba, Mu-Min Shao

  • 1Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, , Hong Kong, Hong Kong.

Journal of Clinical Pathology
|August 8, 2013
PubMed
Summary
This summary is machine-generated.

Columnar cell lesions, typically found in female breasts, have now been identified in male breast tissue. These lesions share similar features and immunohistochemical profiles, suggesting a potential link in male breast pathology.

Keywords:
BreastImmunohistochemistryMorphology

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Published on: October 16, 2010

Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
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Sectioning Mammary Gland Whole Mounts for Lesion Identification
09:22

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Published on: July 24, 2017

Area of Science:

  • Pathology
  • Oncology
  • Breast Cancer Research

Background:

  • Columnar cell lesions (CCL) are recognized precursors in female breast pathology.
  • Their presence and significance in the male breast remain largely uncharacterized.
  • This study investigates male breast ducts exhibiting columnar cell-like features.

Purpose of the Study:

  • To evaluate the occurrence and morphological characteristics of columnar cell-like lesions in the male breast.
  • To assess the immunohistochemical profile (CK5/6 and estrogen receptor) of these lesions.
  • To correlate these findings with clinicopathological features in male patients.

Main Methods:

  • Review of 71 male surgical breast resections.
  • Morphological assessment of dilated ducts for columnar epithelium, apical snouts, secretions, and calcifications.
  • Immunohistochemical analysis for CK5/6 and estrogen receptor (ER) expression.

Main Results:

  • Columnar cell-like features were identified in 39 cases (55%).
  • Lesions showed dilated ducts with inner columnar cells (apical snouts) and outer myoepithelial cells.
  • Immunohistochemistry revealed CK5/6 negativity (38/39) and heterogeneous ER positivity.
  • These changes were associated with older age but not specific to malignancy or hyperplasia.

Conclusions:

  • An entity with morphological and immunohistochemical characteristics of columnar cell lesions exists in the male breast.
  • This finding expands the understanding of breast pathology in males.
  • Further research is warranted to clarify the clinical significance of these lesions in men.