Related Experiment Video
Updated: May 9, 2026
09:51
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Fractal studies on the protein secondary structure elements
1Department of Biochemistry, University of Hyderabad, Hyderabad 500 046.
Indian Journal of Biochemistry & Biophysics
|August 9, 2013
Summary
Protein secondary structures exhibit distinct fractal dimensions, correlating with their abundance. Analysis reveals long-range correlations in protein sequences, potentially aiding prediction algorithms.
Area of Science:
- * Computational biology
- * Structural bioinformatics
- * Biophysics
Background:
- * Protein secondary structures are fundamental to protein folding and function.
- * Understanding the structural organization and sequence patterns is crucial for predicting protein properties.
- * Fractal analysis offers a novel approach to quantify the complexity of biological structures.
Purpose of the Study:
- * To calculate fractal dimensions for protein secondary structure elements.
- * To investigate the relationship between fractal dimensions and secondary structure abundance.
- * To explore sequence correlations using a Markov model.
Main Methods:
- * Calculation of fractal dimensions based on positional distributions of secondary structure elements.
- * Classification of secondary structure elements into distinct groups.
- * Application of a Markov model to analyze sequence transitions.
Main Results:
- * Seven secondary structure elements were grouped into two classes based on fractal dimensions.
- * A negative correlation was found between fractal dimension values and secondary structure abundances.
- * The Markov model indicated the presence of long-range correlations in protein sequences.
Conclusions:
- * Protein secondary structures display quantifiable complexity through fractal dimensions.
- * The identified correlations suggest underlying patterns in protein sequences.
- * These findings may enhance the development of protein prediction algorithms.
Related Concept Videos
01:22Protein Folding
Overview
01:22Protein Folding
Overview
01:25Protein Folding
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
02:15Protein and Protein Structure
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
A protein's shape is critical to its function. For example, an enzyme can...
01:13Protein Organization
Overview
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.