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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
[Colonic diverticulosis: natural history and therapeutic indications]
1Service de chirurgie digestive, Hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France. franck.zinzindohoue@egp.aphp.fr
Abstract:
Colonic diverticulosis defined by the presence of mucosal hernia passing through the colic muscularis is symptomatic due to complications in 10-20% of cases. It affects less than 10% of patients before 40 years old and reaches 80% at 80 years old. Primary prevention is a diet of 25g of dietary fiber per day. We are witnessing a decrease of the number of the resections during the last ten years. The diagnosis requires CT proofs. The most serious complications are often inaugural, and severity of acute accesses decreases then. Emergency cares are often minimally invasive therapies as imaging guided and laparoscopic drainage. Resection is reserved for peritonitis, chronic stenosis, fistula, or persistent diseases despite medical management, in patients with more than 3 outbreaks and patients with specific medical risk or immunocompromised.
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