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RNA replicon delivery via lipid-complexed PRINT protein particles

Jing Xu1, J Christopher Luft, Xianwen Yi

  • 1Department of Chemistry, △Department of Pharmacology, ∥UNC Eshelman School of Pharmacy, †Carolina Center of Cancer Nanotechnology Excellence, ⊥Institute for Advanced Materials, #Institute for Nanomedicine, ¶Lineberger Comprehensive Cancer Center, and ■Department of Biochemistry and Biophysics, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

Molecular Pharmaceutics
|August 9, 2013
PubMed
Summary

Researchers developed a novel lipid-complexed protein particle system for delivering RNA replicons. This system shows promise for RNA replicon-based vaccines, highlighting the need for degradable cross-linkers in particle design.

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