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Manganese Ion-Based NanoPlatforms for Tumor Theranostics
Xiangzhou Li1,2, Wenjing Xie1,2, Xinyu Jin1,2
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Advanced Healthcare Materials
|August 5, 2026
Summary
Manganese-ion nanoparticles offer integrated cancer diagnosis and therapy. This review details their synthesis, diagnostic uses like MRI, therapeutic applications including chemodynamic therapy, and future clinical potential.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Manganese-ion-based nanoparticles are versatile platforms for precision cancer theranostics.
- Integrating diagnostic and therapeutic functions, these nanomaterials offer significant potential in oncology.
Purpose of the Study:
- To review manganese-based nanomaterials using a design-oriented framework.
- To connect synthesis, structure, function, application, and limitations of these platforms.
Main Methods:
- Comparison of mainstream preparation strategies (e.g., thermal decomposition, hydrothermal synthesis, coprecipitation).
- Evaluation of synthesis routes based on physicochemical control, Mn activation, scalability, and biomedical suitability.
Main Results:
- Diagnostic applications include activatable T1-weighted MRI and multimodal imaging.
- Therapeutic modalities encompass chemodynamic therapy, nanozyme activity, drug delivery, and magnetic hyperthermia.
- Mn-activated DNAzyme platforms for gene regulation are also discussed.
Conclusions:
- Manganese-ion nanoplatforms show promise for image-guided combination cancer therapies.
- Critical analysis of biosafety, translational challenges, and future perspectives is provided.
