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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

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Related Experiment Video

Updated: May 9, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Notch signaling represses p63 expression in the developing surface ectoderm.

Ana Mafalda Baptista Tadeu1, Valerie Horsley

  • 1Department of Molecular, Cell and Developmental Biology, Yale University, 219 Prospect Street, Box 208103, New Haven, CT 06520, USA.

Development (Cambridge, England)
|August 9, 2013
PubMed
Summary
This summary is machine-generated.

Notch signaling negatively regulates p63 expression, a key factor in epidermal development. This discovery clarifies how ectodermal cells become keratinocytes, crucial for skin formation.

Keywords:
EctodermKeratinocyte specificationNotch signalingp63

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Last Updated: May 9, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Published on: December 12, 2019

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Epidermal development involves complex signaling and transcriptional regulation.
  • Early specification events of epidermal keratinocytes from ectodermal progenitors are not fully understood.

Purpose of the Study:

  • To investigate the mechanisms controlling keratinocyte fate from ectodermal progenitor cells.
  • To elucidate the role of Notch signaling in early epidermal development.

Main Methods:

  • Utilized developing mouse embryos and human embryonic stem cells (hESCs).
  • Analyzed the expression of p63 and keratin 14.
  • Investigated Notch signaling activation and inhibition (pharmacological and genetic).

Main Results:

  • p63 expression precedes keratin 14 expression in both hESCs and mouse embryos.
  • Notch signaling activation occurs before p63 expression in ectodermal progenitor cells.
  • Inhibition of Notch signaling negatively impacts p63 expression during ectodermal specification.

Conclusions:

  • Notch signaling plays a negative regulatory role in p63 expression.
  • This study reveals Notch signaling's involvement in the molecular control of ectodermal progenitor cell specification to the epidermal keratinocyte lineage.