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Updated: May 9, 2026

The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
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The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)

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VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I

Mayumi Okumura1, Angela M Katsuyama, Hideki Shibata

  • 1Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University.

Bioscience, Biotechnology, and Biochemistry
|August 9, 2013
PubMed
Summary

The endosomal sorting complex required for transport (ESCRT)-I complex interacts with ALG-2, a calcium-dependent adaptor protein. This interaction bridges ALIX and ESCRT-I, forming a crucial ternary complex for cellular functions.

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