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Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Related Experiment Video

Updated: May 9, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Cross-linking for microbial keratitis.

Jayesh Vazirani¹, Pravin K Vaddavalli

¹Cornea and Anterior Segment Service, LV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.

Indian Journal of Ophthalmology

|August 9, 2013

Summary

This summary is machine-generated.

Collagen cross-linking shows promise for keratoconus but has limited data against resistant bacteria. Further research is needed to confirm its efficacy in treating challenging infections.

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Published on: January 6, 2018

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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia

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Published on: January 6, 2018

Area of Science:

Ophthalmology
Microbiology
Biomaterials Science

Background:

Collagen cross-linking (CXL) is established for keratoconus treatment.
Its potential in other applications, including antimicrobial uses, is being explored.
Limited clinical data exists for these novel applications.

Purpose of the Study:

To evaluate the potential of collagen cross-linking as an antimicrobial treatment.
To investigate its efficacy against resistant and slow-growing bacterial strains.
To identify the need for further rigorous studies.

Main Methods:

Review of current clinical and laboratory data on collagen cross-linking efficacy.
Assessment of laboratory findings regarding performance against specific bacterial types.
Analysis of the biological rationale for antimicrobial cross-linking.

Main Results:

Collagen cross-linking shows success in modifying keratoconus.
Laboratory data suggests poor efficacy against resistant and slow-growing bacteria.
Biological plausibility remains a driver for continued investigation.

Conclusions:

Collagen cross-linking's potential beyond keratoconus warrants further investigation.
Efficacy against challenging bacterial infections requires more robust evidence.
Well-designed experimental and clinical studies with controls are essential.