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Biochemical reference values in elderly black subjects.

F C Bester1, D J Weich, H C Barnard

  • 1Department of Internal Medicine, University of the Orange Free State, Bloemfontein.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|September 1, 1990
PubMed
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This study established biochemical reference values for Black South Africans aged 65 and older. Most values aligned with Western populations, but serum total protein and globulin were higher in this group.

Area of Science:

  • Clinical Biochemistry
  • Geriatric Medicine
  • Population Health

Background:

  • Establishing accurate biochemical reference values is crucial for diagnosing and managing health conditions in diverse populations.
  • Limited data exists for biochemical profiles in elderly Black South African populations.
  • Age-related physiological changes can impact biochemical markers.

Purpose of the Study:

  • To determine biochemical reference values for Black individuals aged 65 years and older in an urban South African population.
  • To compare these values with established Western reference ranges.
  • To identify any significant deviations that might indicate specific health concerns.

Main Methods:

  • Biochemical investigations were conducted using the Sequential Multiple Analyser Computer (SMAC) profile, encompassing 20 key clinical chemistry tests.

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  • The study population comprised Black individuals aged 65 and above from the Orange Free State urban area.
  • Data analysis focused on establishing reference ranges for various biochemical analytes.
  • Main Results:

    • Most determined biochemical reference values were comparable to those found in Western populations for similar age groups.
    • No age-related increase in alkaline phosphatase was observed, suggesting a low prevalence of occult Paget's disease.
    • Reference values for serum total protein and globulin were significantly higher compared to elderly White groups.

    Conclusions:

    • The study provides essential biochemical reference data for the elderly Black South African population.
    • The findings suggest potential ethnic or environmental influences on serum total protein and globulin levels.
    • The absence of an alkaline phosphatase age-related rise supports the general health of the studied population regarding Paget's disease.