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Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

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Published on: September 19, 2019

Can head trauma trigger celiac disease? Nation-wide case-control study.

Jonas F Ludvigsson¹, Marios Hadjivassiliou

¹Department of Pediatrics, Örebro University Hospital, Örebro, Sweden. jonasludvigsson@yahoo.com

|August 10, 2013

Summary

Head trauma may slightly increase the risk of developing celiac disease (CD). This study found a small excess risk for future CD in individuals with a history of head trauma.

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Area of Science:

Neuroscience
Gastroenterology
Epidemiology

Background:

Transglutaminase 6 (TG6) is linked to neurological issues in celiac disease (CD).
Head trauma may precede CD, potentially via TG6 and TG2 interactions.

Purpose of the Study:

To investigate if head trauma increases the risk of developing celiac disease (CD).

Main Methods:

A Swedish population-based study analyzed biopsy reports from 29,096 individuals with CD and 144,522 controls.
Conditional logistic regression calculated odds ratios (ORs) for head trauma in CD patients versus controls.

Main Results:

Individuals with head trauma had a 1.10-fold increased risk of future CD (95% CI = 1.02-1.17).
The highest risk was observed within the first year post-trauma, irrespective of trauma severity, sex, or age at CD diagnosis.

Conclusions:

An earlier head trauma is associated with a very small excess risk of developing celiac disease (CD).