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Related Experiment Video

Updated: May 9, 2026

Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy
14:29

Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy

Published on: January 31, 2015

The zebrafish as a model for complex tissue regeneration.

Matthew Gemberling1, Travis J Bailey, David R Hyde

  • 1Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

Trends in Genetics : TIG
|August 10, 2013
PubMed
Summary
This summary is machine-generated.

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Developmental biology·2025

Zebrafish are highly regenerative vertebrates, making them ideal models for studying tissue regrowth. Genetic research in zebrafish reveals key mechanisms underlying regeneration, offering insights for mammalian regenerative strategies.

Area of Science:

  • * Developmental Biology
  • * Comparative Physiology
  • * Genetics and Genomics

Background:

  • * Regeneration in lower vertebrates has long fascinated scientists.
  • * Zebrafish (Danio rerio) possess remarkable regenerative capabilities across multiple tissues.
  • * Their suitability for genetic manipulation makes them a powerful model organism.

Purpose of the Study:

  • * To review the historical and recent contributions of zebrafish research to understanding regeneration.
  • * To explore the genetic and mechanistic underpinnings of tissue repair in zebrafish.
  • * To highlight the relevance of zebrafish regeneration studies for mammalian regenerative medicine.

Main Methods:

  • * Review of existing literature on zebrafish regeneration.
Keywords:
brainfinheartregenerationretinaspinal cordstem cellszebrafish

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Related Experiment Videos

Last Updated: May 9, 2026

Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy
14:29

Capturing Tissue Repair in Zebrafish Larvae with Time-lapse Brightfield Stereomicroscopy

Published on: January 31, 2015

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

High-resolution Cell Transplantation in Embryonic and Larval Zebrafish
06:08

High-resolution Cell Transplantation in Embryonic and Larval Zebrafish

Published on: July 5, 2024

  • * Analysis of genetic approaches (forward and reverse genetics) in zebrafish models.
  • * Synthesis of findings from studies on regeneration in various zebrafish tissues (fin, brain, heart, etc.).

    • Main Results:

    • * Zebrafish exhibit high regenerative capacity in fins, brain, spinal cord, heart, and retina.
    • * Genetic studies have identified numerous genes and pathways crucial for regenerative processes.
    • * Mechanistic insights from zebrafish provide a foundation for understanding regeneration in other species.

    Conclusions:

    • * Zebrafish serve as a premier genetic model for dissecting the fundamental mechanisms of tissue regeneration.
    • * Understanding zebrafish regeneration offers potential pathways for advancing regenerative therapies in humans.
    • * Continued research in zebrafish is vital for unlocking the full potential of regenerative biology.