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Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI

C Federau1, R Meuli, K O'Brien

  • 1From the Department of Diagnostic and Interventional Radiology (C.F., R.M., P.M., P.H.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

AJNR. American Journal of Neuroradiology
|August 10, 2013
PubMed
Abstract

Insights

Intravoxel incoherent motion MRI

Area of Science:

  • Neuroimaging
  • Radiology
  • Oncology

Background:

  • Intravoxel incoherent motion (IVIM) MRI offers a non-invasive method for assessing brain perfusion.
  • Distinguishing between high- and low-grade brain gliomas is crucial for treatment planning.

Purpose of the Study:

  • To evaluate the effectiveness of IVIM perfusion parameters in differentiating high-grade from low-grade brain gliomas.

Main Methods:

  • IVIM perfusion parameters were analyzed in 21 brain gliomas using a Stejskal-Tanner diffusion sequence on 3T MRI systems.
  • Parameters were derived from a biexponential model fit, with analysis of regions of interest and tumor histograms.

Main Results:

  • The perfusion fraction was significantly higher in high-grade gliomas compared to low-grade gliomas and control regions (P < .001).
  • Histograms of perfusion fraction showed a distinct heavy-tailed distribution for high-grade gliomas.
  • No significant difference was found in pseudodiffusion coefficient between groups.

Conclusions:

  • The IVIM perfusion fraction is a valuable parameter for differentiating high-grade from low-grade brain gliomas.
  • IVIM MRI shows promise as an alternative perfusion measurement technique in neuro-oncology.

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