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The beneficial effects of statins in patients undergoing hemodialysis

Chin-Chou Huang1, Wan-Leong Chan, Yu-Chun Chen

  • 1Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C.; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, R.O.C.

International Journal of Cardiology
|August 10, 2013
PubMed

Insights

Statin use significantly reduced cardiovascular events and mortality in hemodialysis patients. This study demonstrates statins

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • The efficacy of statin therapy in patients undergoing hemodialysis remains a subject of debate.
  • Cardiovascular disease is a leading cause of mortality in patients with end-stage renal disease requiring hemodialysis.

Purpose of the Study:

  • To evaluate the association between statin use and the risk of cardiovascular morbidity and mortality in hemodialysis patients.

Main Methods:

  • A cohort study utilized data from the Taiwan National Health Insurance Research Database.
  • Cox regression analysis was employed to compare outcomes between statin users and propensity-matched non-users undergoing hemodialysis.

Main Results:

  • The statin cohort (4074 patients) exhibited significantly lower incidences of ischemic stroke, unstable angina, deep vein thrombosis, cardiovascular mortality, and all-cause mortality compared to the non-statin cohort (8148 patients).
  • Statin use was independently associated with reduced risks for ischemic stroke (HR, 0.49), unstable angina hospitalization (HR, 0.57), deep vein thrombosis (HR, 0.11), cardiovascular mortality (HR, 0.29), and all-cause mortality (HR, 0.49).

Conclusions:

  • Statin therapy is associated with a significant reduction in cardiovascular morbidity and mortality among patients undergoing hemodialysis.
  • These findings support the consideration of statin use in hemodialysis patients to mitigate cardiovascular risks.
Abstract

Keywords:
CardiovascularHemodialysisMorbidityMortalityStatins

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