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Structure and function: how to connect?

Margot J Taylor1

  • 1Diagnostic Imaging, Neurosciences and Mental Health Programme, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada. margot.taylor@sickkids.ca

Neuroradiology
|August 10, 2013
PubMed

Insights

Predicting cognitive difficulties in very preterm infants is crucial. Multimodal MRI studies show early brain differences correlate with later outcomes, aiding timely interventions.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Medical Imaging

Background:

  • Most very preterm-born infants experience cognitive challenges.
  • Early prediction of these difficulties is essential for targeted interventions.

Purpose of the Study:

  • To identify early predictors of cognitive outcomes in very preterm infants.
  • To understand the neurodevelopmental trajectory of preterm-born children.

Main Methods:

  • Multimodal structural and functional magnetic resonance imaging (MRI) in preterm infants.
  • Longitudinal behavioral and neuroimaging assessments up to 4 years of age.
  • Neuroimaging in school-aged preterm children.

Main Results:

  • Early MRI measures (preterm to term age) correlate with 2-year outcomes.
  • Both functional and structural brain differences are observed in school-aged preterm children.
  • Examples of these findings are presented.

Conclusions:

  • Longitudinal structural and functional MRI studies in preterm populations offer critical insights.
  • These studies help elucidate brain-behavior relationships.
  • Predicting outcomes in high-risk preterm individuals is facilitated by neuroimaging.
Abstract

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