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Genetic engineering of T-cell receptors: TCR takes to titin

Helen E Heslop1

  • 1Baylor College of Medicine.

Blood
|August 10, 2013
PubMed

Abstract:

In this issue of Blood, Linette et al report a cautionary tale—a lethal off-target toxicity following T-cell receptor (TCR) optimization to enhance affinity against a tumor-associated antigen, MAGE-A3.

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