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Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
O2-Protected Diazeniumdiolate-Modified Silica Nanoparticles for Extended Nitric Oxide Release from Dental Composites
Alexis W Carpenter1, Katelyn P Reighard, Joseph E Saavedra
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; schoenfisch@unc.edu.
Biomaterials Science
|August 10, 2013
Abstract:
O2-protected N-diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 micromol NO/mg and NO release half-life of 23 d. Reduced (3-log) Streptococcus mutans viable adhesion was observed for NO-releasing dental restorative materials modified with these particles relative to controls.
