Related Experiment Video
Updated: May 9, 2026
10:03
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Global and regional right ventricular dysfunction in pulmonary hypertension
Avin Calcutteea1, Per Lindqvist, Stefan Soderberg
1Department of Public Health and Clinical Medicine and Heart Center, Umeå University, Umeå, Sweden.
Echocardiography (Mount Kisco, N.Y.)
|August 13, 2013
Summary
Pulmonary hypertension significantly impairs right ventricular (RV) function, causing dilation and reduced contractility. This dysfunction alters RV ejection timing and overall pump performance, impacting patient outcomes.
Area of Science:
- Cardiology
- Echocardiography
- Pulmonary Hypertension
Background:
- Pulmonary hypertension (PH) is a known contributor to right ventricular (RV) dysfunction.
- Understanding the specific impacts of PH on RV function is crucial for patient management.
Purpose of the Study:
- To quantify global and regional RV dysfunction in patients with pulmonary hypertension.
- To assess the effects of PH on RV myocardial deformation and timing using speckle tracking echocardiography.
Main Methods:
- A cross-sectional study compared 35 PH patients with 20 controls.
- Speckle tracking echocardiography (STE) assessed RV inflow and outflow tract function, including myocardial strain and strain rate.
- Measurements included dimensions, velocities, TAPSE, ejection/filling times, and pulmonary artery acceleration.
Main Results:
- PH patients exhibited dilated RV inlet and outflow tracts (OTs) compared to controls.
- Significant reductions in RV strain, strain rate, and longitudinal displacement were observed in PH patients.
- Altered timing relationships were noted, with RV inflow tract function becoming critical for peak ejection in PH.
Conclusions:
- Pulmonary hypertension profoundly affects RV structure and myocardial function.
- PH leads to significant disturbances in RV ejection time relations and overall pump performance.
- Increased RV afterload in PH alters RV configuration, shifting ejection determinants from the outflow tract to the inflow tract.
Keywords:
pulmonary hypertensionright ventricleright ventricular outflow tractright ventricular remodelingstrain rate imagingMore Related Videos
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