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Related Experiment Video

Updated: May 9, 2026

Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart

Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart

Published on: June 28, 2024

Heart-brain axis pathophysiological understanding and clinical impact.

Federico Vancheri¹, Sergio Vancheri², Giovanni Longo³

¹Department of Internal Medicine, S. Elia Hospital, Caltanissetta, Italy.

Frontiers in Cardiovascular Medicine

|May 8, 2026

Summary

The heart and brain are intricately linked. This review explores how stroke and heart disease impact each other, highlighting the complex heart-brain axis interactions.

Keywords:

heart-brain axis myocardial infarction stroke stroke-heart syndrome takotsubo (stress) cardiomyopathy

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Last Updated: May 9, 2026

Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart

Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart

Published on: June 28, 2024

Area of Science:

Cardiology
Neurology
Neuroscience

Background:

The heart and brain are interconnected via nervous and humoral pathways, maintaining homeostasis under normal conditions.
Pathological conditions in one organ significantly affect the other, impacting patient prognosis.
The heart-brain axis plays a crucial role in overall health, with disruptions leading to severe consequences.

Purpose of the Study:

To review the pathological interactions within the heart-brain axis.
To explore these interactions in the context of stroke, ischemic heart disease, heart failure, and atrial fibrillation.
To summarize current evidence on the bidirectional communication between the heart and brain.

Main Methods:

Literature review of existing evidence on heart-brain axis interactions.
Analysis of pathological mechanisms linking cardiovascular and cerebrovascular diseases.
Synthesis of findings related to stroke-heart syndrome and cardiac conditions affecting the brain.

Main Results:

Stroke-heart syndrome involves cardiovascular complications like myocardial injury, arrhythmias, and heart failure following ischemic stroke.
Brain damage triggers cardiac injury through neuroinflammation, immune activation, and sympathetic-immune interactions.
Cardiac conditions such as myocardial ischemia, heart failure, and atrial fibrillation increase stroke and cognitive decline risk.

Conclusions:

The heart-brain axis is a critical determinant of health, with bidirectional pathological crosstalk.
Understanding these interactions is vital for managing stroke, heart disease, and related neurological conditions.
Further research into the heart-brain axis mechanisms can lead to improved therapeutic strategies.