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Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

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Updated: May 9, 2026

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
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Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis

Published on: November 3, 2017

Hematogones: an overview.

S P Chantepie1, E Cornet, V Salaün

  • 1Hematology Department, University Hospital, 14 033 Caen Cedex, France.

Leukemia Research
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

Hematogones are normal B-lymphocyte precursors in bone marrow. This review updates knowledge on their features and roles in various blood and non-blood disorders.

Keywords:
B-cell precursorsBone marrow transplantationHematogonesHematological recovery

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Last Updated: May 9, 2026

Application of Aorta-gonad-mesonephros Explant Culture System in Developmental Hematopoiesis
07:38

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Published on: November 3, 2017

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
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Published on: April 10, 2012

Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Area of Science:

  • Hematology
  • Immunology
  • Cell Biology

Background:

  • Hematogones are normal B-lymphocyte precursors found in bone marrow.
  • First described over 70 years ago, their nature was initially unclear.
  • These cells share overlapping properties with lymphoblasts.

Purpose of the Study:

  • To describe the morphological and immunological features of hematogones.
  • To provide an updated understanding of hematogones in various disorders.
  • To clarify the role of hematogones in both hematological and non-hematological conditions.

Main Methods:

  • Review of existing literature on hematogones.
  • Analysis of morphological characteristics in bone marrow smears.
  • Evaluation of immunological markers and phenotypes.

Main Results:

  • Detailed description of hematogones' morphology and immunophenotype.
  • Identification of distinct hematogone populations.
  • Summary of hematogone presence and significance in different disease states.

Conclusions:

  • Hematogones are well-characterized B-lymphocyte precursors.
  • Understanding hematogones is crucial for diagnosing and managing certain hematological and non-hematological disorders.
  • Further research can elucidate their precise functions and clinical implications.