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Related Experiment Video

Updated: May 9, 2026

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Bioengineering heart tissue for in vitro testing.

Elisa Cimetta1, Amandine Godier-Furnémont, Gordana Vunjak-Novakovic

  • 1Columbia University, Department of Biomedical Engineering, 622 West 168th Street, VC12-234, New York, NY 10032, USA.

Current Opinion in Biotechnology
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

Tissue engineering is shifting from large implants to small, human tissue models on microphysiological platforms. These platforms enable high-throughput drug screening and disease modeling using biomimetic heart micro-tissues.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Discovery

Background:

  • Classical tissue engineering focuses on creating implantable tissues using stem cells, scaffolds, and bioreactors.
  • A new paradigm utilizes microphysiological platforms with numerous small human tissues.
  • These platforms are valuable for preclinical drug testing and disease modeling.

Purpose of the Study:

  • To discuss the emerging reverse paradigm in tissue engineering.
  • To highlight the biomimetic approach in designing microphysiological platforms.
  • To detail the design and application of heart micro-tissue platforms for in vitro screening.

Main Methods:

  • Development of microphysiological platforms.
  • Incorporation of biomimetic principles.
  • Utilisation of human stem cells and biomaterial scaffolds.
  • Design of heart micro-tissues for high-throughput screening.

Main Results:

  • Emergence of a reverse paradigm in tissue engineering.
  • Successful design and utilization of heart micro-tissue platforms.
  • Demonstration of platforms for high-throughput in vitro screening.

Conclusions:

  • Microphysiological platforms represent a significant shift in tissue engineering.
  • Biomimetic design is key for effective micro-tissue platforms.
  • Heart micro-tissue platforms offer powerful tools for drug screening and disease modeling.