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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

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A novel protocol to accelerate dynamic combinatorial chemistry via isolation of ligand-target adducts from dynamic

Zheng Fang1, Wei He, Xin Li

  • 1School of Pharmaceutical Science, Nanjing University of Technology, Nanjing, China.

Bioorganic & Medicinal Chemistry Letters
|August 13, 2013
PubMed

Keywords:
Combinatorial chemistryDrug discoveryEnzyme inhibitorsLigand separation

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Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...