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10:32
A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins
Published on: May 29, 2016
Host genetic determinants of influenza pathogenicity
1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, United States.
Current Opinion in Virology
|August 13, 2013
Summary
Influenza remains a global threat despite vaccines. This review highlights recent insights into host genetic factors influencing influenza severity, complementing research on viral determinants.
Area of Science:
- * Virology and Immunology
- * Human Genetics and Disease
Background:
- * Influenza poses a significant global health risk, causing seasonal epidemics and pandemics.
- * Avian influenza (e.g., H7N9) presents a risk of human transmission.
- * Influenza's clinical outcome is influenced by both viral and host genetic factors.
Purpose of the Study:
- * To review and highlight recent advancements in understanding host genetic determinants of influenza.
- * To emphasize the growing importance of human genetic research in influenza pathogenesis.
Main Methods:
- * Review of murine and human studies on influenza.
- * Analysis of genetic factors influencing host response to influenza virus.
Main Results:
- * Host genetic factors play a crucial role in determining the clinical course of influenza.
- * Research into host genetic determinants is rapidly advancing.
Conclusions:
- * Understanding host genetics is essential for managing influenza.
- * Future influenza research should integrate host genetic insights with viral studies.
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