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PELP1: a review of PELP1 interactions, signaling, and biology

Brian J Girard1, Andrea R Daniel1, Carol A Lange1

  • 1Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States.

Molecular and Cellular Endocrinology
|August 13, 2013
PubMed

Insights

Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a versatile protein regulating gene expression and cellular signaling. Its roles in nuclear and cytoplasmic functions impact cancer progression, highlighting its significance in biological processes.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Cancer Biology

Background:

  • Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a multi-domain protein.
  • Initial studies identified PELP1 as an estrogen receptor coactivator.
  • PELP1 functions extend to coregulating transcription factors and chromatin remodeling.

Purpose of the Study:

  • To review the cloning and characterization of PELP1 expression.
  • To explore PELP1 interacting proteins.
  • To elucidate PELP1 signaling pathways and PELP1-mediated biology.

Main Methods:

  • Literature review of PELP1 research.
  • Analysis of PELP1's molecular interactions.
  • Examination of PELP1's role in cellular signaling and cancer.

Main Results:

  • PELP1 acts as a coactivator for multiple transcription factors.
  • PELP1 is a component of chromatin remodeling complexes.
  • PELP1 functions in both nuclear and cytoplasmic compartments, mediating rapid signaling.

Conclusions:

  • PELP1 plays a critical role in both nuclear and cytoplasmic signaling pathways.
  • PELP1 influences key cellular processes, including proliferation and metastasis.
  • Understanding PELP1's multifaceted roles is crucial for cancer biology research.

Keywords:
AIB1ARBCAS3CBPCREB binding proteinChIPCoactivatorE2ERERRαEstrogen signalingExtra-nuclear signalingFHL2GRHDACHormone resistanceIHCILK1KDM1LIM domainLin-1, Isl-1, and Mec-3 domainMNARModulator of Nongenomic Activity of ERPELP1RXRSH2SH3STAT3TIF2amplified in breast cancer 1androgen receptorbreast carcinoma amplified sequence 3c-Src homology domain 2c-Src homology domain 3chromatin immunoprecipitationestradiolestrogen receptorestrogen-related receptor alphafour and a half LIM domains 2glucocorticoid receptorhistone deacetylaseimmunohistochemistryintegrin-linked kinase 1lysine-specific histone demethylase 1proline, glutamic acid and leucine rich protein 1retinoid X receptorsignal transducer and activator or transcription 3transcriptional mediators/intermediary factor 2

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