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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Updated: May 9, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke.

Yuanfei Wang¹, Michael J Cooke¹, Nadia Sachewsky²

¹Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada; Institute of Biomaterials and Biomedical Engineering, 164 College Street, Room 407, Toronto, ON M5S 3G9, Canada.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|August 13, 2013

Summary

This study introduces a novel hydrogel delivery system for sequential growth factor release, promoting neural stem cell repair after stroke. This method minimizes tissue damage compared to traditional infusion techniques.

Keywords:

Controlled delivery Epidermal growth factor Erythropoietin Hydrogel composite Stroke Tissue regeneration

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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

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Last Updated: May 9, 2026

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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Published on: July 27, 2014

Area of Science:

Neuroscience
Biomaterials Science
Regenerative Medicine

Background:

Stroke is a primary cause of long-term disability, lacking effective regenerative therapies.
Stimulating endogenous neural stem/progenitor cells (NSPCs) is a promising repair strategy.
Current delivery methods like intracerebroventricular (ICV) infusion cause significant brain damage.

Purpose of the Study:

To develop a novel, minimally invasive delivery system for sequential growth factor administration to the brain.
To overcome the blood-brain barrier (BBB) for targeted delivery of epidermal growth factor (EGF) and erythropoietin (EPO).
To evaluate the efficacy of this system in promoting tissue repair and minimizing damage in a mouse stroke model.

Main Methods:

Encapsulation of pegylated EGF (EGF-PEG) in PLGA nanoparticles for controlled release.
Encapsulation of EPO in biphasic microparticles (PLGA core, poly(sebacic acid) coating) for controlled release.
Dispersion of EGF-PEG and EPO particles in a hyaluronan methylcellulose (HAMC) hydrogel for spatial confinement and reduced inflammation.

Main Results:

The composite hydrogel system enabled sequential release of EGF-PEG and EPO.
This delivery method successfully promoted tissue repair in a mouse model of stroke.
The novel system demonstrated significantly reduced tissue damage compared to conventional ICV infusion.

Conclusions:

A novel composite hydrogel system facilitates controlled, sequential delivery of EGF and EPO, bypassing the BBB.
This approach effectively stimulates endogenous repair mechanisms, leading to tissue regeneration post-stroke.
The developed delivery system offers a safer and more effective alternative to current methods for stroke treatment.