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Synergistic Immunomodulation and Angiogenesis-Driven Microenvironment Remodeling via Bioactive Hydrogel/Nanofiber
Ziyi Zhou1,2, Dengjun Zhang1, Qingxia Guo2
1Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Advanced Healthcare Materials
|June 19, 2026
Summary
A new multifunctional bilayer wound dressing (MBWD) promotes infectious wound healing by providing hydration, antimicrobial, anti-inflammatory, and pro-angiogenic effects. This advanced dressing enhances recovery for various wound types, including diabetic wounds.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Infectious wounds, including burn, traumatic, surgical, and chronic ulcers, require specific microenvironments for effective repair.
- Key microenvironmental factors include hydration, antioxidant activity, antimicrobial properties, anti-inflammatory effects, and angiogenesis.
Purpose of the Study:
- To develop a multifunctional bilayer wound dressing (MBWD) that addresses the complex needs of infectious wound microenvironments.
- To simultaneously provide hydration, antioxidant, antimicrobial, anti-inflammatory, and pro-angiogenic conditions to promote wound repair and prevent infection spread.
Main Methods:
- Developed a bilayer dressing: inner layer (DMOG@PCL/ASC) with polycaprolactone/fish collagen nanofibers and dimethyloxalylglycine (DMOG) for angiogenesis.
- Outer layer (M-CMCS/CeO2) with modified carboxymethyl chitosan hydrogel and cerium oxide nanozymes for hydration, antimicrobial, antioxidant, and anti-inflammatory effects.
- Evaluated MBWD efficacy in vivo for infectious and diabetic wound healing.
Main Results:
- The inner layer's nanofiber structure supports cell adhesion, while DMOG release promotes angiogenesis.
- The outer hydrogel layer maintains a moist environment and exhibits antimicrobial properties.
- Cerium oxide nanozymes in the outer layer provide antioxidant, antimicrobial, and anti-inflammatory benefits.
- In vivo studies demonstrated enhanced healing of infectious and diabetic wounds with MBWD treatment.
Conclusions:
- The MBWD effectively integrates nanofiber and hydrogel components to create a synergistic system for infectious wound management.
- The dressing simultaneously delivers crucial therapeutic effects, including antimicrobial, anti-inflammatory, and pro-angiogenic actions.
- This multifunctional approach offers a promising strategy for treating complex infectious wounds and improving patient outcomes.
