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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

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Published on: April 16, 2012

Immune regulation by CD52-expressing CD4 T cells.

Ban-Hock Toh1, Tin Kyaw, Peter Tipping

  • 1Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Vic., Australia.

Cellular & Molecular Immunology
|August 13, 2013
PubMed
Summary

CD52-expressing CD4 T cells regulate immune responses through two mechanisms: soluble CD52 inhibiting T-cell activation and CD52 cross-linking promoting T-cell expansion. These findings offer insights into T-cell regulation and potential therapeutic targets.

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Published on: June 22, 2016

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • CD4 T cells play a crucial role in regulating immune responses.
  • CD52 is a cell surface molecule expressed on T cells.
  • The precise regulatory functions of CD52 on CD4 T cells are not fully understood.

Purpose of the Study:

  • To elucidate the mechanisms by which CD52-expressing CD4 T cells regulate T-cell responses.
  • To investigate the role of soluble CD52 and CD52 cross-linking in T-cell activation and expansion.

Main Methods:

  • Analysis of CD52 release from CD4 T cells.
  • Investigating the interaction between soluble CD52 and the Siglec-10 receptor.
  • Studying the effects of CD52 cross-linking using anti-CD52 antibodies on T-cell expansion.
  • Assessing the phosphorylation of T-cell receptor associated lck and zap-70.

Main Results:

  • Soluble CD52 released from CD4 T cells binds to the inhibitory Siglec-10 receptor.
  • This binding attenuates effector T-cell activation by impairing lck and zap-70 phosphorylation.
  • Cross-linkage of CD52 molecules by an unidentified ligand or anti-CD52 antibody induces T-cell expansion.

Conclusions:

  • CD52-expressing CD4 T cells employ dual mechanisms for T-cell regulation: inhibition via soluble CD52 and expansion via CD52 cross-linking.
  • These findings reveal novel pathways in T-cell immune regulation mediated by CD52.
  • Understanding these mechanisms may lead to new therapeutic strategies targeting T-cell responses.