Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

14
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
14
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

11
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
11
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

16
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
16
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

16
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
16
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

14
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
14
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

19
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD39 mRNA therapy attenuates localized acute inflammation: A novel anti-inflammatory strategy using cationic nanoliposomes.

Molecular therapy. Nucleic acids·2026
Same author

Beyond Reperfusion: Early Molecular Drivers and Therapeutic Opportunities in Acute Post-Infarction Cardiac Fibrosis.

International journal of molecular sciences·2026
Same author

Platelet-Targeted Self-Amplifying mRNA for Safe, Long-Acting Thromboprophylaxis.

Circulation research·2026
Same author

Prothrombotic genetic variants and cancer-associated venous thromboembolism: defining thrombotic risk across tumor types.

Haematologica·2026
Same author

Harnessing Immune Pathways for Stroke Recovery: Overcoming Challenges to Clinical Translation.

Circulation research·2026
Same author

Innovative γ-Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery.

Small (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Aug 6, 2025

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.6K

Myocarditis: causes, mechanisms, and evolving therapies.

Tin Kyaw1,2,3, Grant Drummond4,5, Alex Bobik1,2,3,5,6

  • 1Inflammation and Cardiovascular Disease Laboratory, Baker Heart and Diabetes Institute.

Expert Opinion on Therapeutic Targets
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Myocarditis, heart inflammation often caused by viruses or immune checkpoint inhibitors, requires better treatments. A combination of antiviral drugs and immunotherapies targeting T cells may offer the best approach.

Keywords:
Myocarditisimmune checkpoint inhibitorsimmunotherapymRNA vaccinesvaccinevirus

More Related Videos

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K

Related Experiment Videos

Last Updated: Aug 6, 2025

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.6K
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K

Area of Science:

  • Cardiology
  • Immunology
  • Virology

Background:

  • Myocarditis is a severe heart inflammation, primarily triggered by viruses or immune checkpoint inhibitors (ICIs).
  • Recent mRNA vaccine use for SARS-CoV-2 has raised concerns about myocarditis as a rare adverse event.
  • Limited proven treatment options exist for severe myocarditis cases.

Purpose of the Study:

  • To review viral causes of myocarditis, focusing on entry and replication mechanisms.
  • To systematically examine current and novel therapeutic targets for viral myocarditis.
  • To dissect the immune system's role in both viral and ICI-induced myocarditis.

Main Methods:

  • Systematic review of viral myocarditis literature.
  • Analysis of immune system responses in myocarditis.
  • Evaluation of potential therapeutic strategies.

Main Results:

  • Vaccination shows promise for preventing viral myocarditis but needs further development.
  • Antiviral treatments can reduce myocarditis severity by lowering viral load.
  • Understanding post-viral immune damage is key to new therapies.

Conclusions:

  • Viral myocarditis treatment may benefit from combined antiviral agents and immunotherapies.
  • Targeting cytotoxic T cell activity is a promising therapeutic strategy.
  • Further research into vaccine efficacy and immune modulation is warranted.