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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 9, 2026

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
05:40

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

Harnessing Immune Pathways for Stroke Recovery: Overcoming Challenges to Clinical Translation.

Alex Peh1,2,3, Ali Ahmadi1,3, Ahmed Refaat1,2,4

  • 1Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia (A.P., A.A., A.R., M.M., J.N., K.P.).

Circulation Research
|May 7, 2026
PubMed
Summary

Stroke recovery is limited by complex inflammation. Targeting inflammation shows promise but faces translation challenges. New strategies like modulating the gut-brain axis and adaptive trials may improve outcomes.

Keywords:
brain-gut axisinflammationplatelet activationreperfusionstrokethromboinflammationthrombosis

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Last Updated: May 9, 2026

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Area of Science:

  • Neuroscience
  • Immunology
  • Translational Medicine

Background:

  • Stroke is a major cause of death and disability globally.
  • Inflammation plays a critical, complex role in stroke pathophysiology, impacting both injury and repair.
  • Current stroke treatments offer limited options for improving long-term recovery.

Purpose of the Study:

  • To systematically review the role of inflammatory responses in stroke.
  • To integrate insights from experimental and clinical studies on stroke inflammation.
  • To explore emerging therapeutic strategies for stroke recovery.

Main Methods:

  • Systematic review of experimental and clinical studies on stroke inflammation.
  • Analysis of key immune cell populations and signaling pathways.
  • Discussion of progress and limitations in inflammation-targeting clinical trials.

Main Results:

  • Inflammation post-stroke involves thrombo-inflammation, microglial activation, and peripheral immune cell infiltration.
  • These inflammatory processes paradoxically contribute to both tissue repair and injury.
  • Clinical translation of inflammation-targeting therapies has faced significant challenges.

Conclusions:

  • Understanding the dynamic inflammatory response is crucial for stroke recovery.
  • Emerging approaches like targeting thrombo-inflammation and the gut-brain axis offer new therapeutic avenues.
  • Refining therapy development through adaptive trial designs is essential for clinical success.