Related Experiment Video
Updated: May 8, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[Peripheral venous catheter-related E. faecalis sepsis with fatal outcome]
J J Frosinski1, F M Brunkhorst
1Integriertes Forschungs- und Behandlungszentrum Sepsis und Sepsisfolgen, CSCC, Universitätsklinikum Jena, Jena.
History And Admission Findings:
A 82 year-old man was admitted with a facial Herpes zoster reactivation and a zoster-related meningoencephalitis. He was treated with Aciclovir over a peripheral venous catheter that was placed in the right elbow pit. The meningoencephalitis subsided without neurological deficits, but the patient developed a catheter-associated phlebitis. An oral cephalosporin was prescribed and the patient discharged. After developing a fever and general discomfort he was readmitted to hospital three days later.
Investigations:
A 3 × 3 cm abscess in the elbow pit was incised and drained, but no swab or blood cultures were taken. When the patient's condition got worse an echocardiogram was ordered. It showed vegetations on the aortic and mitral valves as well as on the cardiac pacemaker wires.
Treatment And Course:
Blood cultures were positive for Enterococcus faecalis. Although a therapy with vancomycin and ampicillin was started, the patient's condition impaired. Surgical valve replacement was initiated, but the patient expired 5 weeks later due to septic multi-organ failure.
Conclusion:
The danger of peripheral venous catheter infections is frequently underrated, early identification of the causing pathogen, sensitivity testing and proper antibiotic treatment are of tremendous importance. Clinical sings of sepsis must under no circumstances be overlooked.
Related Concept Videos
Endocarditis I: Introduction
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Endocarditis II: Clinical Features of Infective Endocarditis
Acute Pyelonephritis II: Diagnostic Studies and Management
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Endocarditis IV: Nursing Management