Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.

PLoS computational biology·2026
Same author

Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.

Nature. Mental health·2026
Same author

The exposome of brain aging across 34 countries.

Nature medicine·2026
Same author

A <i>KCNC1</i> variant linked to Rett syndrome disrupts ER to Golgi trafficking of Kv3.1 channel.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study.

PLoS computational biology·2025
Same author

Creative experiences and brain clocks.

Nature communications·2025
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Quantitative analysis of cell migration using optical flow.

Katica Boric1, Patricio Orio, Thierry Viéville

  • 1Centro Interdisciplinario de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Plos One
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

Ethanol exposure during development causes subtle defects in zebrafish neural crest cell migration. This study quantified changes in cell movement and asymmetry, revealing potential links to facial development.

More Related Videos

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
08:31

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Related Experiment Videos

Last Updated: May 8, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
08:31

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • Neural crest cells are crucial for development, migrating extensively to form various tissues.
  • Understanding neural crest cell migration is key to deciphering developmental processes and abnormalities.
  • Ethanol is a known teratogen, but its specific effects on neural crest cell migration require detailed quantification.

Purpose of the Study:

  • To develop and apply a novel computational assay for quantifying in vivo neural crest cell migration.
  • To investigate the subtle defects in cranial neural crest cell migration caused by early ethanol exposure in zebrafish.
  • To correlate observed migration changes with potential impacts on facial development.

Main Methods:

  • Utilized a sox10:EGFP transgenic zebrafish line for visualizing neural crest cells.
  • Developed a quantitative assay combining Optical Flow and affine transformation for analyzing cell population migration in time-lapse movies.
  • Compared migration patterns of neural crest cells in ethanol-treated versus untreated zebrafish embryos.

Main Results:

  • Detected and quantified significant differences in cranial neural crest cell migration between ethanol-exposed and control groups.
  • Ethanol exposure increased left-right asymmetry in migrating neural crest cell populations.
  • Altered directions of cell movement were observed in ethanol-treated embryos.

Conclusions:

  • The novel computational method effectively quantifies population-level cell migration and detects subtle defects.
  • Early ethanol exposure induces specific alterations in zebrafish cranial neural crest cell migration dynamics.
  • These migration defects may contribute to facial asymmetries observed in developmental disorders and potentially normal populations.