[The effect of dexmedetomidine on post-operative blood pressure after controlled hypotension in endoscopic sinus surgery]

To observe the variance of blood pressure (BP) after controlled hypotension in endoscopic sinus surgery with dexmedetomidine.

Sixty patients undergoing elective endoscopic sinus surgery were randomly assigned to receive dexmedetomidine (Group D) or physiological saline (Group S). For the two groups, after the same induction of anesthesia procedure, Group D were injected with dexmedetomidine with 0.8 microg/kg of priming dose in 10 min and 0.5 microg/(kg x h) of maintenance dose i. v. drip for 30 min. The Group S were injected with physiological saline in the dose the same as Group D. The measurement of the mean aortic pressure(MAP), heart rate (HR) and the colouration of the Nasal packing material and exudation were taken at the end of the surgery (T1), at the time of extubation (T2), 10 min after extubation (T3), 30 min after extubation (T4), 2 h after extubation (T5), and 4 h after extubation (T6).

The MAP and HR of Group S at the points T2-T6 were significantly higher compared with those at the point T1 (P < 0.05). The MAP and HR of Group D at each time point did not change significantly (P > 0.05). The MAP and HR of Group S at each time point were higher compared with Group D (P < 0.05). The number of cases with postoperative nasal exudate in Group S was significantly more than in Group D (27:18) (P < 0.05).

The perioperative dexmedetomidine medication can significantly reduce fluctuations in BP in endoscopic sinus surgery, so that to stable hemodynamics and reduce nasal bleeding.