Chemically functionalized single-walled carbon nanotube films modulate the morpho-functional and proliferative
Manoj K Gottipati1, Josheua J Samuelson, Irina Kalinina
1Departments of Neurobiology and Biomedical Engineering, University of Alabama , Birmingham, Alabama 35294, United States.
Abstract:
We used single-walled carbon nanotube (CNT) films to modulate the morpho-functional and proliferative characteristics of astrocytes. When plated on the CNT films of various thicknesses, astrocytes grow bigger and rounder in shape with a decrease in the immunoreactivity of glial fibrillary acidic protein along with an increase in their proliferation, changes associated with the dedifferentiation of astrocytes in culture. Thus, CNT films, as a coating material for electrodes used in brain machine interface, could reduce astrogliosis around the site of implantation.


