Related Experiment Video

Updated: Jul 24, 2026

Cryo-electron Microscopy Specimen Preparation By Means Of a Focused Ion Beam
10:54

Cryo-electron Microscopy Specimen Preparation By Means Of a Focused Ion Beam

Published on: July 26, 2014

Electron microscopic investigations of the cryolesion

E W Breitbart1, G Schaeg

  • 1Department of Dermatology, University of Hamburg, Federal Republic of Germany.

Clinics in Dermatology
|January 1, 1990
PubMed
Abstract

No abstract available in PubMed .

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Related Concept Videos

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...