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Upconverting and NIR emitting rare earth based nanostructures for NIR-bioimaging.

Eva Hemmer¹, Nallusamy Venkatachalam, Hiroshi Hyodo

¹Tokyo University of Science, Center for Technologies against Cancer (CTC), 2669 Yamazaki, 278-0022 Chiba, Japan. eva.hemmer@emt.inrs.ca.

|August 14, 2013

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Effect of Disorder on the Emission Spectra of Er<sup>3+</sup>, Tm<sup>3+</sup>, and Yb<sup>3+</sup>-Doped β‑NaYF<sub>4</sub>: Quantum Chemical and Experimental Results.

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Lanthanide-doped nanostructures offer advanced near-infrared (NIR) bioimaging, overcoming limitations of organic dyes for early disease detection and molecular imaging.

Area of Science:

Nanomedicine
Bioimaging
Biomarker Development

Background:

Organic dyes used in bioimaging suffer from photobleaching, autofluorescence, and limited tissue penetration.
Developing novel biomarkers for early disease detection, molecular imaging, and therapy remains critical.

Purpose of the Study:

To review recent advancements in lanthanide-containing inorganic nanostructures for near-infrared (NIR) bioimaging.
To highlight the potential of these nanoprobes for overcoming the limitations of traditional imaging techniques.

Main Methods:

Utilizing lanthanide ions (Ln3+) doped into inorganic nanostructures (e.g., Y2O3:Er3+,Yb3+ and Gd2O3:Er3+,Yb3+).
Focusing on nanoprobes emitting in the NIR range (>1000 nm) under NIR excitation for in vivo applications.

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Main Results:

Lanthanide-doped nanostructures exhibit promising optical and magnetic properties for NIR-NIR bioimaging.
Gadolinium-based nanostructures show potential as opto-magnetic markers, enabling combined optical imaging and MRI.

Conclusions:

NIR-NIR bioimaging using lanthanide-doped nanoprobes offers a solution to the drawbacks of UV/visible light-based imaging.
These advanced nanoprobes are crucial for improved early disease detection, molecular imaging, and targeted therapies.