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Interaction of Mg2+ ions with nucleoside triphosphates by phosphorus magnetic resonance spectroscopy
Nucleic Acids Research
|July 1, 1975
Abstract:
The interaction of Mg2+ with nucleoside triphosphates: ATP, GTP, CTP and UTP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution. The results show that these four nucleotides behave similarly. Purine and Purimidine bases have almost no effect on the phosphate groups even in the N7 pK region of ATP and GTP. The Mg2+ ion binds not to the alpha and alpha but only to the beta phosphate group. The fixation is stronger at neutral pH than at acid pH.