Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Progress Note: Intravenous Human Albumin in Patients With Cirrhosis.

Journal of hospital medicine·2021
Same author

Sleep disturbance in patients with chronic concussive effects.

Concussion (London, England)·2018
Same author

In Reply: Pulmonary tuberculosis.

Cleveland Clinic journal of medicine·2015
See all related articles

Related Experiment Video

Updated: May 8, 2026

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
09:15

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Published on: October 10, 2017

Diabetic foot infections.

Fassil W Gemechu1, Fnu Seemant, Catherine A Curley

  • 1MetroHealth Medical Center, Cleveland, OH, USA. fgemechu@metrohealth.org

American Family Physician
|August 14, 2013
PubMed
Summary
This summary is machine-generated.

Diabetic foot infections, common in diabetes, can lead to amputation. Early diagnosis and treatment, including antibiotics and wound care, are crucial for managing these serious infections.

Related Experiment Videos

Last Updated: May 8, 2026

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
09:15

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Published on: October 10, 2017

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Podiatry

Background:

  • Diabetic foot infection is a major complication of diabetes mellitus, frequently causing hospitalization and lower extremity amputations.
  • Diagnosis relies on clinical signs of inflammation or purulence, with infections categorized by severity (mild, moderate, severe).
  • These infections are often polymicrobial, with Staphylococcus species being the most common pathogens.

Purpose of the Study:

  • To provide a comprehensive overview of diabetic foot infections.
  • To outline diagnostic criteria and classification systems.
  • To discuss current treatment strategies and preventive measures.

Main Methods:

  • Clinical diagnosis based on inflammation or purulence.
  • Classification of infections into mild, moderate, and severe categories.
  • Assessment of treatment based on infection severity and patient comorbidities.

Main Results:

  • Most diabetic foot infections are polymicrobial, predominantly caused by aerobic gram-positive cocci like Staphylococcus.
  • Osteomyelitis is a significant complication, often necessitating surgical intervention.
  • Peripheral arterial disease affects up to 40% of patients, highlighting the importance of vascular assessment.

Conclusions:

  • Treatment varies from oral antibiotics for mild cases to hospitalization and IV antibiotics for severe infections.
  • Preventive strategies include patient education, glycemic control, smoking cessation, and regular foot examinations.
  • Prompt evaluation and management are essential to prevent severe outcomes like amputation.