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Updated: May 8, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Update on oncolytic viral therapy - targeting angiogenesis
James R Tysome1, Nick R Lemoine, Yaohe Wang
1Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom ; Department of Otolaryngology, Cambridge University Hospitals, Cambridge, United Kingdom ; Sino-British Research Center for Molecular Oncology, Zhengzhou University, Zhengzhou, People's Republic of China.
Oncotargets and Therapy
|August 14, 2013
Summary
Oncolytic viruses (OVs) can be engineered to target tumor angiogenesis. Combining OVs with antiangiogenic strategies offers a promising approach to enhance cancer therapy effectiveness.
Area of Science:
- Oncolytic virotherapy
- Cancer biology
- Tumor angiogenesis
Background:
- Oncolytic viruses (OVs) selectively infect and lyse cancer cells.
- Tumor growth relies on angiogenesis, the formation of new blood vessels.
- Current antiangiogenic therapies often have limited efficacy.
Purpose of the Study:
- To review the development and targeting of OVs in cancer therapy.
- To discuss the role of angiogenesis in tumor progression.
- To explore strategies for combining OVs with antiangiogenic approaches.
Main Methods:
- Direct targeting of vascular endothelial cells by OVs.
- Engineering OVs to express antiangiogenic transgenes within the tumor microenvironment.
Main Results:
- OVs can be armed with antiangiogenic transgenes for localized expression.
- Combination therapy aims to overcome limitations of individual approaches.
Conclusions:
- Arming OVs with antiangiogenic transgenes is a developing strategy.
- Further optimization is needed to maximize the therapeutic potential of this combined approach.
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