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Convenient quantification of methanol concentration detection utilizing an integrated microfluidic chip.

Yao-Nan Wang¹, Ruey-Jen Yang, Wei-Jhong Ju

¹Department of Vehicle Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.

Biomicrofluidics

|August 14, 2013

Summary

This study introduces a new method for detecting methanol concentration using a Polymethyl-Methacrylate microfluidic chip. The technique offers a rapid and accurate analysis for alcoholic beverage inspection.

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Area of Science:

Analytical Chemistry
Microfluidics
Chemical Sensing

Background:

Methanol detection is crucial for quality control in alcoholic beverages.
Existing methods can be time-consuming or require complex equipment.
Development of rapid, on-site detection methods is needed.

Purpose of the Study:

To develop a simple and rapid technique for methanol concentration detection.
To utilize a Polymethyl-Methacrylate (PMMA) microfluidic chip for this purpose.
To validate the accuracy and reliability of the developed method.

Main Methods:

Fabrication of a PMMA microfluidic chip using a CO2 laser scriber.
Mixing of methanol and methanol oxidase (MOX) in a circular chamber with vortex stirring.

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Reaction with fuchsin-sulphurous acid followed by UV spectrophotometry.

Comparison with gas chromatography for validation.

Main Results:

High correlation coefficient (R(2) = 0.9940) between optical density and methanol concentration.
Accuracy of 93.1% compared to gas chromatography for concentrations between 2-100 ppm.
Successful detection of methanol in commercial red wine samples.

Conclusions:

The developed microfluidic chip provides a rapid and accurate method for methanol detection.
This technique is suitable for applications in alcoholic beverage inspection and control.
The method offers a cost-effective and efficient alternative for methanol analysis.