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A decision analytic approach to exposure-based chemical prioritization.
Jade Mitchell1, Nicolas Pabon, Zachary A Collier
1Biosystems & Agricultural Engineering, Michigan State University, East Lansing, Michigan, United States of America.
Plos One
|August 14, 2013
Summary
This study introduces a new model for prioritizing chemicals based on their potential exposure risks. It helps identify chemicals needing further testing and risk management strategies for environmental and health safety.
Area of Science:
- Environmental Science
- Toxicology
- Risk Assessment
Background:
- Increasing production of novel synthetic chemicals raises concerns about unknown environmental and health risks.
- Existing risk assessment methods are limited by insufficient hazard and exposure data for most commercial chemicals.
Purpose of the Study:
- To develop a rapid chemical evaluation tool focusing on exposure potential.
- To create a model for prioritizing chemicals for further testing and risk management.
Main Methods:
- Utilized the US Environmental Protection Agency's ExpoCast Program framework.
- Developed a model evaluating chemicals based on inherent properties and life cycle usage.
- Integrated data within a decision analytic framework for prioritization.
Main Results:
- Presented a case study prioritizing 51 chemicals.
- Generated a preliminary relative ranking of chemicals by exposure potential.
- Demonstrated the model's ability to integrate diverse data types.
Conclusions:
- The model facilitates rapid assessment and prioritization of chemicals for targeted testing.
- It integrates statistical, mechanistic data, and expert judgment for informed risk management strategies.
- This approach provides an initial tier assessment for environmental and health safety evaluations.
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