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[Cerebrospinal fluid study in Chinese patients with multiple sclerosis]
1Department of Internal Medicine, Chung-Shan Medical and Dental College Hospital, Taichung, Taiwan, R.O.C.
The demonstration of intrathecally synthesized IgG had been known to be one of the most important aids in diagnosis of multiple sclerosis (MS). Three quantitative methods (CSF IgG, IgG index, de novo IgG synthesis rate) and qualitative detection of oligoclonal band (OB) were used in this study. We collected CSF and serum samples from 22 patients, including 14 with clinically definite MS (DMS) and 8 with clinically possible MS (PMS). The 3 quantitative CSF IgG index were significantly increased in DMS group (p less than 0.05) as compared with normal control group, but not in PMS group. There was no difference in the positive rate of OB between DMS and PMS (both are 50%). The relationship between IgG index and various clinical condition in DMS patients are as following: The 3 CSF IgG index were increased only in the patients with younger age onset, shorter duration, higher relapsing rate, spinal form and disease in relapsing stage. The positive rate of OB was increased only in the patients with longer duration and higher relapsing rate. The follow-up study showed the presence of OB was not change while the disease was remissive. It was concluded that CSF IgG, IgG index, de novo IgG synthesis rate had good correlation with clinical diagnosis, and were good reference for clinical course, disease activity, and therapeutic effect in Chinese patients with MS.(ABSTRACT TRUNCATED AT 250 WORDS)
The demonstration of intrathecally synthesized IgG had been known to be one of the most important aids in diagnosis of multiple sclerosis (MS). Three quantitative methods (CSF IgG, IgG index, de novo IgG synthesis rate) and qualitative detection of oligoclonal band (OB) were used in this study. We collected CSF and serum samples from 22 patients, including 14 with clinically definite MS (DMS) and 8 with clinically possible MS (PMS). The 3 quantitative CSF IgG index were significantly increased in DMS group (p less than 0.05) as compared with normal control group, but not in PMS group. There was no difference in the positive rate of OB between DMS and PMS (both are 50%). The relationship between IgG index and various clinical condition in DMS patients are as following: The 3 CSF IgG index were increased only in the patients with younger age onset, shorter duration, higher relapsing rate, spinal form and disease in relapsing stage. The positive rate of OB was increased only in the patients with longer duration and higher relapsing rate. The follow-up study showed the presence of OB was not change while the disease was remissive. It was concluded that CSF IgG, IgG index, de novo IgG synthesis rate had good correlation with clinical diagnosis, and were good reference for clinical course, disease activity, and therapeutic effect in Chinese patients with MS.(ABSTRACT TRUNCATED AT 250 WORDS)