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[Cerebrospinal fluid study in Chinese patients with multiple sclerosis]
1Department of Internal Medicine, Chung-Shan Medical and Dental College Hospital, Taichung, Taiwan, R.O.C.
Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology
|May 1, 1990
Summary
Quantitative cerebrospinal fluid (CSF) IgG tests, including IgG index, show correlation with multiple sclerosis (MS) diagnosis and clinical course in Chinese patients. Oligoclonal band (OB) detection also aids in assessing disease activity.
Area of Science:
- Neurology
- Immunology
- Biochemistry
Context:
- Intrathecally synthesized immunoglobulin G (IgG) is crucial for diagnosing multiple sclerosis (MS).
- Quantitative and qualitative methods are used to assess IgG synthesis in cerebrospinal fluid (CSF).
Purpose:
- To evaluate the diagnostic and prognostic value of quantitative CSF IgG measurements and oligoclonal band (OB) detection in Chinese MS patients.
Summary:
- Three quantitative CSF IgG indices were elevated in definite MS (DMS) but not possible MS (PMS) patients compared to controls.
- No significant difference in OB positivity was found between DMS and PMS groups.
- CSF IgG indices correlated with younger age of onset, shorter disease duration, higher relapse rates, spinal form, and active relapsing disease stages.
Impact:
- Quantitative CSF IgG markers correlate well with clinical diagnosis, disease course, activity, and therapeutic response in Chinese MS patients.
- OB presence remained stable during remission, suggesting its utility in long-term disease monitoring.