Related Experiment Video
Updated: May 8, 2026
12:22
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma
1State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Changle West Road #169, Xi'an 710032, China.
British Journal of Cancer
|August 15, 2013
Summary
Ribosomal S6 protein kinase 4 (RSK4) is overexpressed in renal cell carcinoma (RCC), correlating with advanced disease and poor prognosis. RSK4 may serve as a novel therapeutic target for RCC patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- The role of ribosomal S6 protein kinase 4 (RSK4) in renal cell carcinoma (RCC) remains uncharacterized.
- Understanding RSK4's expression and function is crucial for advancing RCC treatment strategies.
Purpose of the Study:
- To investigate the expression pattern of RSK4 in RCC.
- To determine the correlation between RSK4 expression and clinicopathological features and prognosis in RCC patients.
- To elucidate the molecular mechanisms underlying RSK4's role in RCC progression.
Main Methods:
- Immunohistochemistry was employed to assess RSK4 expression in RCC tissues.
- Statistical analysis was performed to correlate RSK4 levels with patient outcomes and disease characteristics.
- In vitro studies using RCC cell lines examined the impact of ectopic RSK4 expression on cell cycle, invasion, and metastasis.
Main Results:
- RSK4 was significantly overexpressed in RCC compared to normal tissues, with varied expression across RCC subtypes.
- Elevated RSK4 expression correlated positively with advanced tumor stage, higher Fuhrman grade, lymph node metastasis, and distant metastasis.
- Overexpression of RSK4 promoted cell cycle progression and enhanced the invasive and metastatic potential of RCC cells.
Conclusions:
- RSK4 exhibits a distinct expression pattern in RCC and influences key oncogenic processes.
- RSK4 represents a potential independent prognostic biomarker for RCC.
- RSK4 emerges as a promising novel therapeutic target for managing renal cell carcinoma.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:22PI3K/mTOR/AKT Signaling Pathway
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...