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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Diterpenoids of terrestrial origin.

James R Hanson¹

¹Department of Chemistry, University of Surrey, Brighton, BN1 9QJ, UK.

Natural Product Reports

|August 15, 2013

Summary

This review details the isolation and chemistry of terrestrial diterpenoids, including various classes like labdanes and clerodanes, published in 2012. It covers their cyclization products, drawing from 169 references.

Area of Science:

Natural Product Chemistry
Organic Chemistry

Background:

Diterpenoids are a significant class of natural products with diverse chemical structures and biological activities.
Terrestrial sources are rich in a wide array of diterpenoid compounds.

Purpose of the Study:

To provide a comprehensive overview of the isolation and chemical characterization of diterpenoids from terrestrial origins.
To review advancements in the chemistry of labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes, and their cyclization products.

Main Methods:

Literature review of scientific publications from January to December 2012.
Focus on isolation and structural elucidation of diterpenoids from non-marine sources.
Categorization of compounds based on their core skeletal structures.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

Main Results:

Compilation of 169 references detailing the isolation and chemistry of various terrestrial diterpenoids.
Inclusion of key diterpenoid subclasses such as labdanes, clerodanes, abietanes, pimaranes, kauranes, and cembranes.
Discussion of cyclization products derived from these diterpenoid skeletons.

Conclusions:

The year 2012 saw continued exploration and characterization of terrestrial diterpenoids.
Understanding the chemistry of these compounds is crucial for natural product research and drug discovery.