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Updated: May 5, 2026

A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy
Published on: April 30, 2015
Hepatic venoocclusive disease and perisinusoidal fibrosis secondary to arsenic poisoning
H Labadie1, P Stoessel, P Callard
1Service d'Hépatogastroentérologie, Hôpital Jean Verdier, Bondy, France.
Abstract:
Hepatic injury secondary to arsenic poisoning has been known long but is poorly documented. A case of a patient with hepatic injury following severe arsenic poisoning is reported. Histological study of the liver demonstrated acute venoocclusive disease and perisinusoidal fibrosis. This case indicates that arsenic poisoning causes veno-occlusive disease in humans. It also suggests that hepatic damage in arsenic poisoning is secondary to vascular endothelial injury and supports the hypothesis that different patterns of hepatic vascular injury might proceed from a common mechanism.
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