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Correlation between Corneal Topographic Indices and Higher-Order Aberrations in Keratoconus
Sepehr Feizi1, Bahram Einollahi, Alireza Raminkhoo
1Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Ophthalmic & Vision Research
|August 15, 2013
Summary
Corneal higher-order aberrations (HOAs) are significantly elevated in keratoconic eyes compared to normal eyes. Corneal irregularity, particularly in the 3-mm zone, strongly correlates with these increased HOAs in keratoconus patients.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Wavefront Aberrometry
Background:
- Keratoconus is a progressive corneal ectasia characterized by thinning and irregular protrusion.
- Corneal higher-order aberrations (HOAs) significantly impact visual quality and are often pronounced in keratoconus.
Purpose of the Study:
- To compare corneal HOAs between normal and keratoconic eyes.
- To investigate the relationship between corneal topographic indices and wavefront data in keratoconus.
Main Methods:
- Cross-sectional study comparing 77 normal eyes and 66 keratoconic eyes.
- Corneal topography (Orbscan II) and wavefront analysis (Galilei Scheimpflug analyzer) were performed.
- Statistical analysis included t-tests and Spearman correlation.
Main Results:
- Keratoconic eyes exhibited significantly higher Zernike coefficients (except specific trefoil/tetrafoil aberrations) and total HOAs compared to normal eyes.
- Strongest associations in keratoconus were between vertical coma and total HOAs with 3-mm zone irregularity.
- Spherical and vertical coma aberrations correlated with mean keratometry.
Conclusions:
- Corneal HOAs are significantly greater in keratoconic eyes, particularly in the central cornea.
- Anterior and inferior corneal displacement contributes to the HOAs observed in keratoconus.
