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Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: May 8, 2026

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

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Programmable ion-sensitive transistor interfaces. II. Biomolecular sensing and manipulation.

Krishna Jayant1, Kshitij Auluck, Mary Funke

  • 1School of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA. kj75@cornell.edu

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|August 16, 2013
PubMed
Summary

This study demonstrates a metal-oxide-semiconductor transistor for DNA adsorption monitoring and manipulation. Injected charges control DNA binding, enabling programmable sensor interfaces for biomolecule interaction.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Metal-oxide-semiconductor (MOS) transistors can be functionalized for biosensing applications.
  • Understanding DNA molecule adsorption and interaction is crucial for developing advanced biosensors.

Purpose of the Study:

  • To utilize a chemoreceptive neuron MOS transistor for monitoring DNA adsorption and interaction.
  • To demonstrate the manipulation of adsorbed DNA molecules using injected static charge.
  • To investigate the underlying mechanisms of DNA adsorption modulation and manipulation.

Main Methods:

  • Utilized a poly-L-lysine-coated sensing gate (SG) in a MOS transistor structure.
  • Measured threshold voltage shifts (V(th_CG)) in response to DNA adsorption.
  • Employed simulation studies to analyze the effect of counterion screening.
  • Investigated DNA manipulation via electron/hole tunneling onto floating gates (FGs).
  • Applied impedance spectroscopy with a split ac-dc technique to analyze interface impedance.

Main Results:

  • DNA adsorption on SGs modulated the floating gate (FG) potential, causing measurable V(th_CG) shifts.
  • Asymmetric capacitive coupling amplified V(th_CG) shifts.
  • V(CG)-driven readout induced a larger electric field in the SG oxide, enhancing V(th_CG) shifts due to counterion screening.
  • Injected electrons (programming) caused DNA desorption, while injected holes (erasing) reestablished adsorption.
  • Pre-addition of charge influenced DNA immobilization, enabling addressable sensor interfaces.

Conclusions:

  • The developed MOS transistor effectively monitors and manipulates DNA adsorption.
  • Injected charge provides a mechanism for controlling biomolecule interactions on sensor surfaces.
  • This technology offers potential for creating programmable and addressable biosensor interfaces.