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Related Experiment Video

Updated: May 8, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Platelet aggregation following trauma: a prospective study.

Nis A Windeløv¹, Anne M Sørensen, Anders Perner

¹aDepartment of Anaesthesia bTrauma Centre, Centre of Head and Orthopaedics, cDepartment of Intensive Care, The Abdominal Centre dDepartment of Cardiothoracic Anaesthesia and Intensive Care, The Heart Centre eSection for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark fDepartment of Surgery, Centre for Translational Injury Research, University of Texas Medical School, Houston, Texas, USA.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis

|August 16, 2013

Summary

Platelet function in trauma patients is crucial for hemostasis. Higher TRAP values indicate a higher risk of death from cerebral injury, while lower platelet counts are linked to massive transfusions.

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Last Updated: May 8, 2026

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Published on: April 6, 2017

Area of Science:

Trauma and Emergency Medicine
Hematology
Clinical Coagulation

Background:

Platelet function is critical for hemostasis but poorly understood in trauma patients.
Investigating platelet aggregation in trauma is essential for improving patient outcomes.

Purpose of the Study:

To investigate platelet aggregation capacity in adult trauma patients.
To determine the association between platelet function and clinical outcomes like injury severity, massive transfusion, and mortality.

Main Methods:

Prospective observational study of 213 adult trauma patients.
Platelet aggregation analyzed using multiple electrode aggregometry (Multiplate device) with TRAP or collagen.
Blood samples collected median 65 minutes post-injury; Injury Severity Score (ISS) recorded.

Main Results:

No significant association found between platelet aggregation response and ISS.
Higher TRAP values correlated with death due to cerebral injuries (P < 0.01).
Lower platelet counts were associated with massive transfusion (P < 0.01).

Conclusions:

No simple relationship exists between platelet aggregation and overall injury severity.
Elevated platelet aggregation (TRAP) is linked to fatality from cerebral injuries.
Platelet count is a significant predictor for massive transfusion requirements in trauma.