Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Computationally guided genome rewiring of Escherichia coli and its application for nanopolyethylene terephthalate (PET) biodegradation and upcycling.

Trends in biotechnology·2025

Same author

Reduction-responsive immobilised and protected enzymes.

Nanoscale advances·2024

Same author

Exploring the Potential of Various Cyclodextrin-Based Derivatives in Enzyme Supramolecular Engineering.

Chembiochem : a European journal of chemical biology·2024

Same author

Biodegradation of untreated plasticizers-free linear low-density polyethylene films by marine bacteria.

Marine pollution bulletin·2024

Same author

Atomically precise surface chemistry of zirconium and hafnium metal oxo clusters beyond carboxylate ligands.

Chemical science·2024

Same author

Pollutant profile complexity governs wastewater removal of recalcitrant pharmaceuticals.

The ISME journal·2024

Search research articles

Related Experiment Video

Updated: May 8, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

Cyclodextrin-based combinatorial polymers: efficient binders of pharmaceuticals in water.

Patrick Shahgaldian¹, Philippe F-X Corvini

¹University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz, Switzerland. patrick.shahgaldian@fhnw.ch

|August 16, 2013

Summary

Cyclodextrins form polymers that can selectively capture pharmaceuticals in water. Polymer chemistry significantly impacts binding effectiveness, enabling the creation of targeted pharmaceutical sorbent nanomaterials.

More Related Videos

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Related Experiment Videos

Last Updated: May 8, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

Supramolecular Chemistry
Polymer Science
Analytical Chemistry

Background:

Cyclodextrins, cyclic glucose oligomers, possess molecular inclusion properties valuable in various industrial applications.
Their unique structure allows for the encapsulation of guest molecules, driving their widespread use.
Developing selective recognition systems for pharmaceuticals in aqueous environments remains a significant challenge.

Purpose of the Study:

To synthesize and characterize polymer libraries derived from cyclodextrins.
To evaluate the efficacy of these cyclodextrin-based polymers in the selective recognition of pharmaceuticals in water.
To establish a strategy for creating tailored nanomaterials for pharmaceutical separation.

Main Methods:

Preparation of diverse polymer libraries utilizing cyclodextrins as building blocks.
Testing the binding capabilities of synthesized polymers for pharmaceutical recognition in aqueous solutions.
Analysis of the influence of polymer chemical composition on binding affinity and selectivity.

Main Results:

Demonstrated that the chemical makeup of the cyclodextrin-based polymers critically affects their pharmaceutical binding properties.
Identified specific polymer compositions that exhibit enhanced selectivity for certain pharmaceuticals.
Confirmed the feasibility of using this strategy to create functional nanomaterials.

Conclusions:

Cyclodextrin-based polymers offer a versatile platform for developing selective pharmaceutical recognition systems.
The chemical design of these polymers is a key factor in achieving desired binding characteristics.
The developed strategy provides a pathway for producing advanced sorbent nanomaterials for pharmaceutical applications.