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Hard tissue replacement (HTR) polymer as an implant material
1Department of Oral Medicine and Pathology, New York University College of Dentistry, New York 10010.
Journal of Biomedical Materials Research
|August 1, 1990
Summary
Hard Tissue Replacement polymer (HTR) shows good compatibility and physical attachment in bone and soft tissues. While promoting new bone growth, HTR is not osteogenic, meaning it does not induce bone formation in non-bony sites.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Orthopedic Research
Background:
- Synthetic implant materials are crucial for tissue regeneration.
- Evaluating biocompatibility and tissue integration is essential for new biomaterials.
Purpose of the Study:
- Assess Hard Tissue Replacement (HTR) polymer's compatibility with bone and soft tissues.
- Determine HTR's capacity for physical attachment to various tissues.
- Investigate HTR's potential for bone induction and metaplasia.
Main Methods:
- HTR implants were placed in rat femurs, connective tissue, and skeletal muscle for 3 weeks.
- Histological examination assessed tissue compatibility and attachment.
- Infrared absorption analysis evaluated new bone formation in bone implant sites.
Main Results:
- High compatibility observed: 93% in bone, 78% in connective tissue, 100% in muscle.
- Physical attachment varied: 71% in bone, 44% in connective tissue, 14% in muscle.
- New bone density increased with HTR, but no metaplasia occurred in non-bony sites.
Conclusions:
- HTR demonstrates significant biocompatibility and physical attachment potential, particularly in bone.
- The material appears to support new bone formation but is not osteogenic.
- HTR shows promise as an effective implant material for bone applications.