Related Experiment Video
Updated: May 8, 2026
10:02
Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
Published on: April 29, 2011
[Influence of pressure- and volume-controlled ventilation on pulse pressure variations: randomized study]
A Guillon1, F Espitalier, S Ehrmann
1Service de réanimation médicale, université F.-Rabelais, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France.
Annales Francaises D'Anesthesie Et De Reanimation
|August 17, 2013
Summary
Pulse pressure variation (ΔPP) is a key fluid responsiveness predictor. However, ΔPP values differ significantly between volume-controlled ventilation (VVC) and pressure-controlled ventilation (VPC), indicating they are not interchangeable.
Area of Science:
- Critical care medicine
- Respiratory physiology
- Hemodynamic monitoring
Context:
- Pulse pressure variation (ΔPP) is a dynamic predictor of fluid responsiveness.
- The influence of different mechanical ventilation modes on ΔPP is not well understood.
- Accurate hemodynamic assessment is crucial in critically ill patients.
Purpose:
- To compare ΔPP values derived from volume-controlled ventilation (VVC) and pressure-controlled ventilation (VPC).
- To determine if ΔPP measurements are interchangeable between these two ventilation modes.
Summary:
- A randomized, cross-over study compared ΔPP in 26 intensive care unit patients post-cardiac surgery.
- ΔPP was measured during both VVC and VPC, with other ventilation parameters held constant.
- Mean ΔPP was 14.0±7.3% in VVC versus 11.8±6.2% in VPC (P<0.0001), with a mean bias of +2.2±2.3%.
Impact:
- ΔPP values are not interchangeable between VVC and VPC.
- A decrease of over two points in ΔPP is observed when switching from VVC to VPC.
- Clinicians must consider the ventilation mode when interpreting ΔPP for fluid responsiveness.
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