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Updated: Nov 4, 2025

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
[Identification of a metabolic immune regulator in the host that protects against influenzal pneumonia]
A Cezard1, A Guillon2, M Si-Tahar1
1Inserm, Centre d'Étude des Pathologies Respiratoires (CEPR), UMR 1100, Tours, France; Université de Tours, Tours, France.
Abstract:
The 'flu, caused mostly by influenza A and B viruses, represents a major public health issue. Despite vaccines and antiviral drugs, the therapeutic arsenal is still suboptimal. Recently, several studies have reported the antiviral and anti-inflammatory properties of several host metabolites. Now, we show that a metabolite (called here "C2") has a potent anti-influenza activity by blocking the viral replication and by limiting the downstream pro-inflammatory signalling. These results pave the way for the development of innovative metabolic therapy against influenzal pneumonia.
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